# Director Louis Leterrier is a big fan of Clash of the Titans (1981), having watched it in his childhood.

# Originally, Stephen Norrington was going to direct the film, but as he hadn't seen the original film he wasn't sure he could make a new yet faithful remake, so in June 2008 he handed the project over to Louis Leterrier.

# Concept designer Aaron Sims considers designing Medusa his most difficult task: "Are they all the same snake in her hair? Do they look more like hair? Are they different in silhouette or in light? And how much of a human face does she have, or is it more like a snake? I worked on one design, and people said it reminded them of Lord Voldemort because there was no nose. You have to be careful so it still looks like it's an original idea."

# Director Louis Leterrier frequently requested that Ray Harryhausen, co-producer and visual effects creator of Clash of the Titans (1981), be involved in the film. However, Harryhausen had retired in 1981 and would not be drawn back.

# Liam Neeson took a role in this film because his sons are big fans of Greek mythology.

# The volcano scenes were shot at the Dinorwic Slate Quarry in Wales. This is a notorious location, used for fantasies like Willow (1988) and Street Fighter (1994).

# An orchestral version of "The Bird and the Worm", a rock song by The Used, was composed for this film.

# James Woods was hoping to play Hades, a part he had previously done in Hercules (1997) but on a more comedic level.

# According to the filmmakers, the mechanical owl Bubo from Clash of the Titans (1981) has an appearance in this film. His cameo scene was widely debated as to whether to keep it in the film or not. It was eventually decided to keep it in the film to please the fans of the original film.

As I understand it, the main thing one needs to consider while editing in 3-D is that no single shot can be shorter than 2 seconds. Any shorter than that and the brain doesn’t have time to adjust to the new 3-D surroundings and cannot properly process the information, leaving you confused and a little off balance if you cut away too soon.