Penny Marshall, the nasally and good-natured Bronx native who starred on the ABC ratings sensation Laverne & Shirley before shattering records as a top-grossing female director in Hollywood, has died. She was 75.

The younger sister of the late writer-director-producer Garry Marshall and the first wife of actor-director Rob Reiner, Marshall died in her Hollywood Hills home on Monday night from complications from diabetes, her publicist Michelle Bega told The Hollywood Reporter on Tuesday. She was diagnosed with brain and lung cancer in 2009.