List a show that meets all of the following criteria

eccentric boss/owner
level headed manager/executive
Quirky assistant/underling/employee
Hot female Employee
Ego Maniac

One character can fufill multiple criteria (for example, a hot quirky assistant)

I'll start with a few obvious ones

NewsRadio
Suddenly Susan
Just Shoot Me


add to the list...

D

WKRP in Cincinnati

Carlson
Travis
Les/Johnny
Jennifer/Bailey
Herb

Working
Almost Perfect
Cheers (depending on the season)

das

You forgot the "Dumb Guy."

How about "Fawlty Towers"?

eccentric boss/owner -- Basil
level headed manager/executive -- Sybil
Quirky assistant/underling/employee -- Manuel
Hot female Employee -- Pauly
Ego Maniac -- Basil
Dumb Guy -- The Major

Life with Bonnie

eccentric boss/owner -- David
level headed manager/executive -- Bonnie/Mark
Quirky assistant/underling/employee -- Tony/Marv
Hot female Employee -- Holly
Ego Maniac -- David (maybe Bonnie)
Dumb Guy -- Marv


D

Mary Tyler Moore Show (possibly the prototype):

eccentric boss/owner - Lou
level headed manager/executive - Murray
Quirky assistant/underling/employee - (the Betty White character, among others)
Hot female Employee - Mary
Ego Maniac - Ted

M*A*S*H

eccentric boss/owner -- Colonel Blake/Potter
level headed manager/executive -- Radar
Quirky assistant/underling/employee -- Klinger
Hot female Employee -- Hot Lips
Ego Maniac -- Frank/Winchester
Dumb Guy -- Frank

Good Morning Miami

Any workplace comedy ever in the history of television.

Um ... I mean "How about the KACL portions of Frasier and the Tool Time portions of Home Improvement?"

you think we could include scrubs and the office?

Bosum Buddies

The season where they ran their own ad agency.