Didn't see another thread discussing this, so thought I'd start one.

For me, there's only one game right now I'm looking forward to playing and that is....

Dragon Age Origins

COD6
RE5
and Bioshock 2 (maybe 2010)

Killzone 2
RE5
Heavy Rain
Resistance: Retribution
MLB The Show 09
Uncharted 2
Alan Wake ?

The next Call of Duty

Is there ever going to be a new twisted metal Game? I would love too see that soon if it happens.

Resident Evil 5

I'm hoping for a 2009 release of Diablo III. I am not holding my breath though.

Ghostbusters
Chronicles of Riddick

Ghostbusters. Definitely.

I really hope Ghostbusters turns out to be a good game and not a steaming pile of crap. It looks promising but then i think of all the other games that are based off of movies.

I'm also looking forward to Final Fantasy 13 and versus if it comes out this year.

Batman: Arkham Asylum
Wii Sports Resort
Wii Punch Out!!

Skate 2
Prototype
Beatles Game

Rock Band 3

Killzone 2
Ghostbusters
Beatles Game
New Ratchet & Clank
Peggle XBLA

Skate 2.

Diablo 3, Starcraft 2, God of War 3... if any of them come out in the next year.

360
Afro Samurai
Halo Wars
Splinter Cell: Conviction
Street Fighter 4
Red Faction
Fight Night Round 4
Tom Clancy's HAWK
Star Ocean: The Last Hope
Darksiders: Wrath of War
Resident Evil
Bayonetta
FF XIII

PS3
Killzone 2

DS
Elebits
Gauntlet
GTA: China Town
Legacy of Ys: Book 1 & 2
Dragon Quest 5
Blue Dragon Plus
Suikoden Tierkreis
Valkyrie Profile: COTP
Fire Emblem
Rhythm Heaven
Witch's Tale

Wii
Little King's Story
Dead Rising: CTYD
Tenchu
House of the Dead: TO
Madworld
The Conduit
FF: Crystal Chronicles EOT

Street Fighter 4. There's not a whole lot else right now on the horizon, although i'm hopeful for Alan Wake or Final Fantasy XIII.

Day 1 purchases
Bioshock 2
Halo: ODST
Rock Band: Beatles
Chronicles of Riddick: Assault on Dark Athena

Wait and see purchases
Ghostbusters
Halo Wars
Peggle XBLA
Lode Runner XBLA
Mad World
Wii Sports Resort
God of War III
Ratchet & Clank

God of War III
COD
Ghostbusters
Bioshock 2
RE 5
Killzone 2
Gran Turismo 5
Red Faction
Infamous
more Ratchet and Clank

Hydrophobia
HAWX
Uncharted 2
Rock Band: Beatles
White Knight Chronicles
Street Fighter 4
FFXIII
Tekken 6

I thought Gran Turismo 5 wasn't coming until 2010.

Definitely borrowing from some of the answers above:

Resident Evil 5
Rock Band: The Beatles
Batman: Arkham Asylum
Wii Punch-Out!!
Bioshock 2
Street Fighter 4
Tekken 6
Ghostbusters

I guess this includes PC games?

what about Diablo III and Starcraft II

Wanted
RE5
Batman:Arkham Asylum
Ghostbusters

So far....nothing. I think Activision has another Bond game planned for '09, though. I hope they put more effort into the Wii version than they did with Quantum of Solace. Otherwise, I'm interested to hear if there will be another entry in the LEGO series that interests me, and that's just about it unless there's a country version of Guitar Hero. (Yes, I'm the player in the demographic that ruins things for you "real gamers.")

I think it's rumored to be in development. That's one I'll be looking forward to as well, but without any sort of official announcement right now, it seems unlikely to be out in 2009.

I'm also really looking forward to Resident Evil 5, Bioshock 2, and MadWorld.

Bioshock 2
God of War 3
Street Fighter 4
Resident Evil 5