most have been pretty lame

i liked Spinal Tap though

I liked the one with Alec Baldwin, Kim Basinger, and Ron Howard... especially seeing Ron and Alex get creamed by the RV. :D

By far the funniest celebrity cameo ever on the Simpsons was James Woods. Too funny.

James Woods
or
John Waters

It seems if your initials are JW, you're gonna have a good cameo on the Simpsons! ;)

I thought the Moody Blues were really funny!

Phil Hartman as Lionel Hutz... of course, he was a recurring character so that probably doesn't count as a cameo. :(

what about the Lamest ?

Bette Midler
Luke Perry
James Woods

Gary Coleman.

The Who

"Whatchew talkin' 'bout EVERYONE!"

J

I liked Paul and Linda McCartney in the episode Lisa declares her vegetarianism. Can't beat a flying pig!
Or a ripping lentil soup recipe.

James Woods' guest appearance was simply hilarious!

Peter Frampton
"Hey you kids, get out of my cooler!"

James Woods was great though, especially cleaning the oven

The best ones are the rock band cameos:

Spinal Tap
Smashing Pumpkins
Cypruss Hill
Aerosmith

Also, the baseball ringers in the Softball episode.

The Softball episode is great: "Mattingly, shave those sideburns!"

Also sideshow Luke Perry: "aaaah, my beautiful face!"

Yes! This is the syndicated episode (Flaming Moe's) on at 6:30 in DC tonight!

John Waters

Albert Brooks (Scorpio)

I like Gary Coleman, they make fun of him every time, hehe

I liked Ed Norton as the grifter

Stephen Jay Gould.

George Harrison. "It's been done."

George C. Scott. Does that count?

Betty White, in "Missionary: Impossible".

Jay Mohr playing Christopher Walken

Aerosmith
Fox Mulder & Dana Scully