If you have a definitive #1, go ahead and tell us.

My favorite song of all-time is 1979 by The Smashing Pumpkins

"More Than a Feeling" - Boston

"(Sittin' On) The Dock of the Bay" - Otis Redding

"Why Does It End?" by the Flaming Lips

"Interstate Love Song" - Stone Temple Pilots

Take Me Home, Phil Collins (Serious Hits Live Version)

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The Rolling Stones - Sympathy For The Devil

whiskeytown - bar lights

"Battery" - Metallica

for the 1970's: Little Willy by Sweet
for the 1980's: Kyrie by Mr. Mister
for the 1990's: To Be With You by Mr. Big

One Headlight - The Wallflowers

1960 - 1969: Born To Be Wild by Steppenwolf
1970 - 1979: I Heard It Through The Grapevine by Creedence Clearwater Revival
1980 - 1989: Wanna Be Startin' Somethin' by Michael Jackson
1990 - 1999: November Rain by Guns N' Roses
2000 - 2009: Red, White, & Pink Slip Blues by Hank Williams, Jr.

1999 - Prince

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"I'll Be Mellow When I'm Dead" -- Weird Al Yankovic

Not a gag answer. I have my reasons.

My typical answer is "God Only Knows" by The Beach Boys.

Solsbury Hill - Peter Gabriel

Sometime To Return - Soul Asylum

Either Yellow Ledbetter by Pearl Jam or Gimme Shelter from the Stones

You Enjoy Myself by Phish followed very closely by A Day in the Life by The Beatles

Lots of contenders, but I'll have to with my usual answer. Great video, too. I love how the camera gradually changes focus from the fire onto the singer at the opening.

Just My Imagination - The Temptations

Levon Helm's version of Atlantic City

Stinkfist - TOOL

So many and it depends on the mood.

Can't choose just one.