Upon watching the finale, 'Meditations in an Emergency', at the 46:03 mark, just after Betty says, "I" and clears her throat, the camera cuts back to Don, at which point the frame appears to be sliced in half vertically towards the center of the screen just over his shoulder. It appears as though it's composed of two shots spliced together, and I can clearly see them shift slightly (the wallpaper pattern goes off and his shirt lifts to the right of the splice line).

I'm wondering if anyone else noticed this, or if by chance this could be a disc/player error? I'm using a PS3 and on the dimly lit scenes I'm noticing more grain/flicker than reviews suggest, thus the player concerns.

I just checked (though I have the SD DVD, not the Blu Ray), and what you described is on my release as well, so it's definitely on the source and not your specific copy and/or player.

Wow, weird. Never noticed it before. It looks like Don's arm/shoulder is subtly trying to escape his body.

Thanks for taking a look.
And that's exactly what I thought when I saw it too