The 10-episode serialized drama, created, directed and executive produced by Rodriguez, will feature a principal cast including D.J. Cotrona (Dear John, G.I. Joe: Retaliation) as Seth Gecko, the role that famously launched the film career of George Clooney. Zane Holtz (Holes, The Perks of Being a Wallflower) stars as Richie Gecko, and Jesse Garcia (Quinceañera, "Sons of Anarchy") plays Texas Ranger Freddie Gonzalez, a new character created for the series. Don Johnson (Django Unchained, "Nash Bridges") will play Sheriff Earl McGraw in a recurring role.

“From Dusk Till Dawn: The Series” is a supernatural crime saga centered around bank robber, Seth Gecko (Cotrona) and his violent, unpredictable brother, Richard “Richie” Gecko (Holtz), who are wanted by the FBI and Texas Rangers Earl McGraw (Johnson) and Freddie Gonzalez (Garcia) after a bank heist left several people dead. While on an escape route to Mexico, Seth and Richie encounter former minister Jacob Fuller and his family who they take hostage. Using the family RV to make a run for the Mexican border, chaos ensues when the group detours to a strip club that is unknowingly populated by vampires, and forces them to fight until dawn in order to get out alive. The series deepens the tone of the film, adds new characters and backstories and expands the Mesoamerican mythology behind the vampires.