• The mistake Michael made was not by having sex with Lucille II, but by playing Thing in Tobias' Fantastic Four show. Before Gob forces him to swallow the forget me not, Michael is in a banana stand polo rather than the outfit he was wearing when trying to sleep with Lucille II. This also throw another theory into play that Michael might've put Lucille II in the banana stand (there's always money in the banana stand) to recover after she fell down the stairs due to her vertigo.
  
  
• One theory has Gene Parmesan being the "murderer" of Lucille II based upon him buying knives earlier in the season.
  
  
• Rebel's mother is actually Tracy Bluth's twin sister which means George Michael finally got sleep with a cousin and Michael slept with his niece.

What the hell happened to Lucille 2 anyway and will we ever find out?

That said, so glad to see this show is back and hopefully it can return again - maybe without the cast split up quite so much or so clumsily.

Favorite episodes - all the Tobias and Gob ones, and the Maebe one turned out surprisingly good considering she's my least favorite character.

Worst episodes - I love Jeffrey Tambor but somehow the plots of his episodes never quite came together for me (Why did he and Oscar switch personalities so much? Was this ever explained?)

Best guest star - Ben Stiller did a terrific job bringing Tony Wonder back.

Worst guest star - Seth Rogen's George Sr is just bad, took me out of the show every time he appeared. Wiig did a much better job as Lucille.

Best development - I love how George Michael's character changed and grew up, of all the cast he probably "changed" the most.

Worst development - Not enough Buster, and his sole episode was kind of a letdown for me - the big hand felt just kind of overcooked and I didn't buy his relationship with Mrs Love one bit.

The macha root thing basically turns you into the opposite of what you are. George Sr. was dominant and in charge in the previous 3 seasons, but it turned him into a whiny sissy. Oscar was a whiny sissy when we saw him, so it turned him into the dominant and in charge one. That was my take on it.

The theories I've heard are all based upon the fact they were not eating maca root. One of the posts on the AD subreddit:

"So I was going back and watching the episode again when I noticed Marky Bark wearing this T-shirt when he first meets Lindsey. http://i.imgur.com/URncb7p.jpg

I was wondering what Qat is and did a little research and found out it's more commonly known as Khat, plant said to cause stimulant like effects. http://en.wikipedia.org/wiki/Khat

In contrast nothing on the web about the maca root brings up any drug like effects except that its used as an aphrodisiac. I suspect Oscar was actually eating this and thats why he suddenly he was getting around so much through out the season. http://en.wikipedia.org/wiki/Lepidium_meyenii (Maca wiki page)"

Other posters pointed out:

"I don't know if this is significant but Oscar mentions a commode uphill from the maca root. I feel like somebody was eating shit. [...] I believe it has something to do with birth control that some women at the seminar were on. Their pee contaminated the maca, but Oscar sweated it out, George Sr. let it sit and now his testosterone is off the charts!"

"they could also be eating mescaline. Marky Barks mom mentions mescaline multiple times, the active hallucinogenic compound in some cacti that grow in the dessert. peyote, san pedro, perivuan torch. [...] Oscar had mescaline cacti growing outside his trailer in the lemon grove."

"Maca root was also word play. George Sr. had covered to Judaism when he did Caged Wisdom, a series of motivational tapes. He was also trying to get 'back on top' after the fall of the family, and Lucile going to prison, so he was taking the macher (which in Yiddish, means "big shot") route, trying to get back on top and not being the "best big brother ever". Macher route, maca root..."