South Park

"The ultimate hypocrite is not Comedy Central — that's their decision not to show the image of Muhammad or not — it's Parker and Stone. Like little whores, they'll sit there and grab the bucks. They'll sit there and they'll whine and they'll take their shot at Jesus. That's their stock in trade." — Donohue, in a statement about South Park creators Parker and Stone following the "Cartoon Wars Part II" episode.

Parker and Stone had criticized their home network, Comedy Central, for refusing to display an image of Muhammad in a South Park episode. Though the image of Muhammad was not present, an image of Jesus Christ (a recurring character on the show), depicted defecating on an American flag and President Bush, was left intact in the episode, which many claimed illustrated the network's own hypocrisy. [23] This depiction was presented on the fictional basis that it was a counter-attack against the US for allowing a Family Guy episode to air with an image of Muhammad. The final scene of the "Cartoon Wars Part II" episode, in which the terrorists broadcast an anti-American film, serves to illustrate the hypocrisy of the censorship decision. It raises the question, "Why is this acceptable to air, when an image of Mohammed, 'just standing there, looking normal', is not?"

On 4 April 2007, South Park parodied Donahue in eleventh series episode "Fantastic Easter Special" as a power-hungry official of the Catholic Church, overthrowing the Pope and sentencing Jesus to death. He is killed at the end of the episode by Jesus.