CSI: CRIME SCENE INVESTIGATION is a fast-paced drama about a team of forensic investigators trained to solve crimes by examining the evidence. They are on the case 24/7, scouring the scene, collecting the irrefutable evidence and finding the missing pieces that will solve the mystery. D.B. Russell, the CSI Supervisor for the grave shift is a family man and scientist, but not a nerd. Son of hippie parents, he's a "Left Coast" Sherlock Holmes who devours crime novels and looks at every crime scene as if it were a story waiting to be told.

Other CSI members include Julie Finlay, the team's Assistant Night Shift Supervisor who worked with D.B. in Seattle; Nick Stokes, the conscience of the team, often driven by his emotional connection to the victim to always get the job done; Sara Sidle, aka Mrs. Grissom, the moral compass of the team who is relentless in her pursuit of criminals; Greg Sanders, once an off-beat tech analyst and now an experienced and intuitive crime solver; and Morgan Brody, an exile from the Los Angeles Crime Lab and the daughter of Undersheriff Ecklie. She's a natural born investigator who still has a lot to learn about politics and family. The CSI team members also work closely with Captain Jim Brass, a seasoned detective and protector of CSI, sometimes to a fault; Dr. Albert Robbins, the ever-professional medical examiner; his wise-cracking assistant, David Phillips; and David Hodges, a tech of many talents who often rubs people the wrong way, but never fails to deliver.