It could be like Die Hard where McClean can't enjoy Christmas ever again. Sam Jackson just keeps telling himself that "This flight will be different. Ain't nuthin' gonna happen."
Maybe the monsters could be robot snakes or something entirely different like ticks or dogs with rabies. I think it has to stay on a plane though. The monsters are arbitrary. The scary part is that you are on the plane with them.

(Just thought of this because I'm wearing my SOAP Tshirt today. I'm one of the few that still think it was a funny idea.)

I doubt we will, unless the DVD has spectacular sales. Maybe as a straight-to-video sequel with no big stars.

Snakes on a helicopter?

Snakes on a ship?

with the box office it pulled.. no way

Too small.

Too big and not in flight.

I guess that since I am afraid of flying in real life the plane thing really drives home the terror. It really is a scary place to be even without some kind of monster on the loose.

If everyone on the interntet that wanted to see a sequel sent in a dollar we'd have ....30 bucks.

Oh well. I guess you're right. Ain't gettin' made.

Maybe DTV with Wesely Snipes.

Snakes on the International Space Station

The obvious sequel would be: Snakes on a Train

There already is a Snakes on a Train

Its a spoof film

Snakes in Spain, starring Antonio Banderas.

Snakes on a Plain

A Discovery Channel Documentary

Drake's Cake's on a Plane? (as long as its not liquid or gel)

Direct to video only. The first didn't light up the box office, given all the hype. So I doubt New Line will want to make a sequel anytime soon.

You heard it here first: Wolverines On A Submerine

Japanese Beetles on a Helicopter.

Sea Bass on a ship. (Not ill-tempered or mutated!)


Both of my ideas will be box office smashes. 200 Million opening night, EACH!

we could have snakes on an island with a "reality show" that was supposed to be survivor like reality show... you know we want some of those people to get bitten by some corral snake....

Snakes in a Port-a-Potty