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there may finally be a HIV vaccine

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there may finally be a HIV vaccine

Old 12-01-04, 08:46 PM
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there may finally be a HIV vaccine

very good news

http://my.webmd.com/content/Article/97/104268.htm

Nov. 29, 2004 -- It worked in mice. It worked in monkeys. And now in humans, a therapeutic vaccine has stopped HIV in its tracks.

The vaccine is made from a patient's own dendritic cells and HIV isolated from the patient's own blood. Dendritic cells are crucial to the immune response. They grab foreign bodies in the blood and present them to other immune cells to trigger powerful immune system responses to destroy the foreign invaders.

HIV infection normally turns these important immune system responses off. But animal studies show that when dendritic cells are "loaded" with whole, killed AIDS viruses, they can trigger effective immune responses that keep infected animals from dying of AIDS.

Wei Lu, Jean-Marie Andrieu, and colleagues at the University of Paris in France and Pernambuco Federal University in Recife, Brazil, tested the vaccine on 18 Brazilian patients. All had HIV infection for at least a year. Their T-cell counts -- a crucial measure of AIDS progression -- were dropping, meaning their disease was worsening. None was taking anti-HIV medications.

After getting three under-the-skin injections of the tailor-made vaccine, the amount of HIV in the patients' blood (called the viral load) dropped by 80%. After a year, eight of the 18 patients still had a 90% drop in HIV levels. All patients' T-cell counts stopped dropping.

The findings appear in the December issue of Nature Medicine.

"The results suggest that [these] vaccines could be a promising strategy for treating people with chronic HIV infection," Andrieu and colleagues write. "The significant decrease of viral load as well as maintenance of ... [T-]cell counts observed at one year after immunization are particularly promising."

The researchers warn that their study is only proof of principle. It's still not clear which patients do best with the vaccine, although there's evidence that vaccination should be given as soon after HIV infection as possible. Only clinical trials comparing people who get the vaccine to those who don't can show whether this vaccine really is an effective AIDS therapy.

Similar approaches are being explored for the treatment of cancer and long-term viral infections such as hepatitis C.
EDIT: Here is a link to the scientific crap

http://www.nature.com/cgi-taf/DynaPa...ll/nm1147.html
Old 12-01-04, 08:50 PM
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HELL YEAH!!!!!!!!
Old 12-01-04, 08:52 PM
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Woot. Intravenous drugs. BONG!
Old 12-01-04, 08:52 PM
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wow. amazing
Old 12-01-04, 08:53 PM
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Bring back the bathhouses baby!!!!

Oh, wait...
Old 12-01-04, 08:54 PM
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Magic Johnson has had the cure for years it seems like.
Old 12-01-04, 08:56 PM
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Two great big
Old 12-01-04, 08:56 PM
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I thought a "vaccine" was for prevention
Old 12-01-04, 08:56 PM
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magic is the cure
Old 12-01-04, 09:06 PM
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Looks promising.

-pedagogue
Old 12-01-04, 09:13 PM
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"The results suggest that [these] vaccines could be a promising strategy for treating people with chronic HIV infection,"
There's a non-chronic type of HIV infection?
Old 12-01-04, 09:49 PM
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Guys, we've been through this drill about 15 times over the past two decades. All previous HIV vaccines have looked really promising at first, and then evaporated. Either they're short-term solutions, or they only work against certain strains of HIV (which mutates rapidly), or they're just inexplicably inconsistent.

Don't get too excited yet.

- David Stein
Old 12-01-04, 09:58 PM
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I hope this works. But somehow I doubt it's going to go anywhere.
Old 12-01-04, 10:00 PM
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Originally posted by wabio
I thought a "vaccine" was for prevention
That's what I thought too. This seems to be a cure, or at least something that places the virus in a 'hibernation' state.

If it were a vaccine, you'd need take it BEFORE you contracted the initial virus (which given "vaccination should be given as soon after HIV infection as possible" seems not to be the case).
Old 12-01-04, 10:03 PM
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After a year, eight of the 18 patients still had a 90% drop in HIV levels.
What about the other ten?
Old 12-01-04, 10:09 PM
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Originally posted by naughty jonny
That's what I thought too. This seems to be a cure, or at least something that places the virus in a 'hibernation' state.

If it were a vaccine, you'd need take it BEFORE you contracted the initial virus (which given "vaccination should be given as soon after HIV infection as possible" seems not to be the case).
who is going to volunteer for that experiment? Maybe they will do it in north korea?
Old 12-01-04, 10:12 PM
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Originally posted by Joe Molotov
There's a non-chronic type of HIV infection?
In the 1980's there was something called ARC, or AIDS Related Complex. A person with HIV would get AIDS like symptoms, but then the person would get well and keep on living. They would never get full blown AIDS and it looked like they had some kind of resistance to the virus.

I've also read somewhere that an HIV like virus killed like 80% of all chimps a few million years ago, and the ones who lived had a natural immunity. The people that show resistance to the virus are thought to have this immunity that has been passed down over millions of years.
Old 12-01-04, 10:28 PM
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Awesome! Now I can pee in everyone's butt!

Old 12-01-04, 10:47 PM
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Wonderful, now were in for a much worse global disease.
Old 12-01-04, 10:49 PM
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Originally posted by shaun3000
What about the other ten?
Wellll...let's just say that fish gotta eat too!
Old 12-01-04, 11:07 PM
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"Well, I don't know how much AIDS y'all, but I've got a theory. The day they come out with the cure for AIDS, guaranteed one shot no problem cure? On that day there's going to be fucking in the streets man. 'IT'S OVER!!!! Who are you? Come here!! What's your name baby? No, it's over! Yeah..WOOOHOOO!!' Man, if you can't get laid on that day, cut it off."

-Bill Hicks
Old 12-01-04, 11:13 PM
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Originally posted by DVD Polizei
Awesome! Now I can pee in everyone's butt!
Dude, stop! We're not there yet!
Old 12-01-04, 11:15 PM
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Interesting. But, if they can't figure out a cure for the common cold yet, I'd reserve the yippee for the time being.
Old 12-01-04, 11:17 PM
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Wow. Even if it's not "the cure" it's nice to know we're getting closer.

Old 12-01-04, 11:45 PM
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Like David said, don't get too excited yet. The HIV virus mutates very rapidly. It would be interesting to see what happens at 5 years or 10 years.

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