Go Back  DVD Talk Forum > General Discussions > Other Talk
Reload this Page >

Doctors grow new Jaw in mans back [merged]

Other Talk "Otterville" plus Religion/Politics

Doctors grow new Jaw in mans back [merged]

Old 08-27-04, 02:30 PM
  #1  
BDB
DVD Talk Legend
Thread Starter
 
Join Date: Jan 2001
Location: Seattle
Posts: 21,049
Received 1 Like on 1 Post
Doctors grow new Jaw in mans back

This is a bit cool. this is part of the article check the link for it all

http://www.cnn.com/2004/TECH/science....ap/index.html

LONDON, England (AP) -- A German who had his lower jaw cut out because of cancer has enjoyed his first meal in nine years -- a bratwurst sandwich -- after surgeons grew a new jaw bone in his back muscle and transplanted it to his mouth in what experts call an "ambitious'' experiment.

According to this week's issue of The Lancet medical journal, the German doctors used a mesh cage, a growth chemical and the patient's own bone marrow, containing stem cells, to create a new jaw bone that fit exactly into the gap left by the cancer surgery.

Tests have not been done yet to verify whether the bone was created by the blank-slate stem cells and it is too early to tell whether the jaw will function normally in the long term.

But the operation is the first published report of a whole bone being engineered and incubated inside a patient's body and transplanted.

Stem cells are the master cells of the body that go on to become every tissue in the body. They are a hot area of research with scientists trying to find ways to prompt them to make desired tissues, and perhaps organs.


Old 08-27-04, 03:04 PM
  #2  
DVD Talk Hall of Fame
 
Join Date: Aug 2002
Location: Seattle
Posts: 8,978
Likes: 0
Received 0 Likes on 0 Posts
Sounds like that woman who had the tumor that grew hair and teeth
Old 08-27-04, 04:26 PM
  #3  
DVD Talk Hero
 
Join Date: Feb 2000
Location: Rosemount, MN
Posts: 32,127
Likes: 0
Received 20 Likes on 13 Posts
That's actually pretty cool.

How badly would it suck to have to have your jaw removed?
Old 08-27-04, 04:39 PM
  #4  
DVD Talk Ultimate Edition
 
Join Date: Jun 2000
Location: Upright, in a cool, dry place
Posts: 4,243
Likes: 0
Received 0 Likes on 0 Posts
So he'll soon be talking out his ass?
Old 08-27-04, 04:40 PM
  #5  
DVD Talk Hero
 
Numanoid's Avatar
 
Join Date: Aug 2000
Location: Down in 'The Park'
Posts: 27,882
Likes: 0
Received 0 Likes on 0 Posts
Originally posted by Quatermass
So he'll soon be talking out his ass?
If by "ass" you mean "back", then...well, still no.
Old 08-27-04, 04:43 PM
  #6  
DVD Talk Legend
 
Join Date: Jun 2001
Location: Texas! Damn right.
Posts: 11,089
Likes: 0
Received 0 Likes on 0 Posts
They missed!
Old 08-27-04, 04:44 PM
  #7  
DVD Talk Legend
 
Join Date: Apr 2002
Posts: 20,726
Likes: 0
Received 0 Likes on 0 Posts
Originally posted by Roto
Sounds like that woman who had the tumor that grew hair and teeth
Aw. fuck it, man! Thanks for brining back that nightmare!
Old 08-27-04, 05:19 PM
  #8  
DVD Talk Legend
 
Bronkster's Avatar
 
Join Date: Aug 2002
Location: AnaheimLand, SoCal
Posts: 15,848
Likes: 0
Received 0 Likes on 0 Posts
Originally posted by Quatermass
So he'll soon be talking out his ass?
Of all the backbiting comments ... !

So, stem cells were used, huh? A baby died so this guy could eat a sandwich? Unthinkable!

Old 08-27-04, 05:28 PM
  #9  
DVD Talk Legend
 
Chad's Avatar
 
Join Date: Sep 1999
Location: Somewhere Hot Scoville Units: 9,999,999 Zodiac Sign: Capricorn
Posts: 11,253
Likes: 0
Received 0 Likes on 0 Posts

CT scan shows new jaw in place.

Wow.
Old 08-27-04, 05:42 PM
  #10  
bhk
DVD Talk Legend
 
Join Date: May 1999
Location: Right of Atilla The Hun
Posts: 19,749
Likes: 0
Received 0 Likes on 0 Posts
According to this week's issue of The Lancet medical journal, the German doctors used a mesh cage, a growth chemical and the patient's own bone marrow, containing stem cells, to create a new jaw bone that fit exactly into the gap left by the cancer surgery.
What! you can get stem cells without embryos?!!!! I never knew.






(Actually I did but seems like the people who want embryonic stem cell research to be an issue for Nov. don't want people to know this)

Last edited by bhk; 08-27-04 at 05:45 PM.
Old 08-27-04, 05:51 PM
  #11  
DVD Talk Hero
 
JasonF's Avatar
 
Join Date: Jul 2001
Location: Washington, DC
Posts: 39,619
Received 0 Likes on 0 Posts
Originally posted by bhk
What! you can get stem cells without embryos?!!!! I never knew.

(Actually I did but seems like the people who want embryonic stem cell research to be an issue for Nov. don't want people to know this)
It's always gotta be political with you, doesn't it?

My understanding is that generally, scientists believe embryonic stem cells to be more versatile, and therefore more promising to be applied to a wide variety of therapies. This isn't to say adult stem cells are useless -- as this procedure demonstrates. But the general belief is we'll be able to do more with embryonic stem cells than we will be able to do with adult stem cells.

And now, to bring this back on topic, here's another picture of what was grown in the patient's back.













Old 08-27-04, 05:54 PM
  #12  
DVD Talk Legend
 
Join Date: Feb 2000
Location: Ferment
Posts: 19,548
Likes: 0
Received 0 Likes on 0 Posts
You can get stem cells from bone marrow, then grow them into any kind of cell you want, from what I've read. They don't all come from fetuses.

Using stem cells from your own body to grow bits you need is a great idea because your body is far less likely to reject said bits, if it rejects those bits at all.

It would be awesome to regrow jaws or organs you need.

Besides, it's better than that russian dude who had his pinky finger chopped off and then attached to his groin so he could have a penis again after losing his last one to cancer.

I wonder if it extends out when he drinks tea?
Old 08-27-04, 05:56 PM
  #13  
DVD Talk Hero
 
Numanoid's Avatar
 
Join Date: Aug 2000
Location: Down in 'The Park'
Posts: 27,882
Likes: 0
Received 0 Likes on 0 Posts
Originally posted by mllefoo
It would be awesome to regrow jaws
Expect a call from Spielberg's lawyers.
Old 08-27-04, 05:57 PM
  #14  
bhk
DVD Talk Legend
 
Join Date: May 1999
Location: Right of Atilla The Hun
Posts: 19,749
Likes: 0
Received 0 Likes on 0 Posts
But the general belief is we'll be able to do more with embryonic stem cells than we will be able to do with adult stem cells.
Perhaps, but there is no ban on private research. Anyways, I'm happy for the guy.
Old 08-27-04, 06:01 PM
  #15  
DVD Talk Legend
 
Join Date: Apr 2002
Posts: 20,726
Likes: 0
Received 0 Likes on 0 Posts
Originally posted by mllefoo
Besides, it's better than that russian dude who had his pinky finger chopped off and then attached to his groin so he could have a penis again after losing his last one to cancer.
Coming up on Nip/Tuck next week!
Old 08-27-04, 06:08 PM
  #16  
DVD Talk Legend
 
Join Date: Aug 2002
Location: Bay Area, CA
Posts: 14,806
Likes: 0
Received 0 Likes on 0 Posts
Originally posted by Chad

new jaw in place.

Wow.
Sweet, you didn't tell me the guy was a cyborg...
Old 08-27-04, 06:20 PM
  #17  
DVD Talk Hero
 
JasonF's Avatar
 
Join Date: Jul 2001
Location: Washington, DC
Posts: 39,619
Received 0 Likes on 0 Posts
Originally posted by bhk
Perhaps, but there is no ban on private research. Anyways, I'm happy for the guy.
True. The media (and, to be fair, liberal politicians) have been playing fast and loose with what Bush did and did not ban with respect to stem cell research. It's not a ban on stem cell research, or even embryonic stem cell research. It's a rule that government funding cannot be used for embryonic stem cell research unless the embryonic stem cells come from one of the lines in existence at the time Bush enacted the policy (August 2001). On the other hand, Bush payed fast and loose with how many viable lines were in existence at that time. It would be nice if someone (Bush, Kerry, anyone!) would be upfront about stem cells, but it doesn't seem like it's going to happen.

Anyway, I agree with you -- very good news for this guy, and for others who could benefit from this or similar procedures.
Old 08-27-04, 06:23 PM
  #18  
DVD Talk Hero
 
Th0r S1mpson's Avatar
 
Join Date: Apr 1999
Location: Seattle, WA
Posts: 36,443
Likes: 0
Received 0 Likes on 0 Posts
Originally posted by mllefoo
I wonder if it extends out when he drinks tea?
!

I don't know why, but that was one of the funniest things I've read in a long time.

[gives mllefoo a delicious cracker]
Old 08-29-04, 02:39 PM
  #19  
DVD Talk Platinum Edition
 
Join Date: Sep 1999
Location: The sprawling metropolis of Manassas Park, VA USA
Posts: 3,616
Likes: 0
Received 0 Likes on 0 Posts
Doctors grow new jaw in man's back

WOW...perhaps we really should take the brakes off the stem cell research...

http://www.cnn.com/2004/TECH/science....ap/index.html


Arrows show a titanium cage, in which patient's new jaw was grown, implanted under his shoulder blade.

LONDON, England (AP) -- A German who had his lower jaw cut out because of cancer has enjoyed his first meal in nine years -- a bratwurst sandwich -- after surgeons grew a new jaw bone in his back muscle and transplanted it to his mouth in what experts call an "ambitious'' experiment.

According to this week's issue of The Lancet medical journal, the German doctors used a mesh cage, a growth chemical and the patient's own bone marrow, containing stem cells, to create a new jaw bone that fit exactly into the gap left by the cancer surgery.

Tests have not been done yet to verify whether the bone was created by the blank-slate stem cells and it is too early to tell whether the jaw will function normally in the long term.

But the operation is the first published report of a whole bone being engineered and incubated inside a patient's body and transplanted.

Stem cells are the master cells of the body that go on to become every tissue in the body. They are a hot area of research with scientists trying to find ways to prompt them to make desired tissues, and perhaps organs.

But while researchers debate whether the technique resulted in a scientific advance involving stem cells, the operation has achieved its purpose and changed a life, said Stan Gronthos, a stem cell expert at the Institute of Medical and Veterinary Science in Adelaide, Australia.

"A patient who had previously lost his mandible (lower jaw) through the result of a destructive tumor can now sit down and chew his first solid meals in nine years ... resulting in an improved quality of life,'' said Gronthos, who was not connected with the experiment.

The operation was done by Dr. Patrick Warnke, a reconstructive facial surgeon at the University of Kiel in Germany. The patient, a 56-year-old man, had his lower jaw and half his tongue cut out almost a decade ago after getting mouth cancer. Since then, he had only been able to slurp soft food or soup from a spoon.

In similar cases, doctors can sometimes replace a lost jawbone by cutting out a piece of bone from the lower leg or from the hip and chiseling it to fit into the mouth.

This patient could not have that procedure because he was taking a potent blood thinner for another condition and doctors considered it too dangerous to harvest bone from elsewhere in his body since extraction leaves a hole where the bone is taken, creating an extra risk of bleeding.

Artificial jaws made from plastic or other materials are not used because they pose too much of a risk of infection.

"He demanded reconstruction,'' Warnke said. "This patient was really sick of living.''

Warnke and his group began by creating a virtual jaw on a computer, after making a three-dimensional scan of the patient's mouth.

The information was used to create a thin titanium micro-mesh cage. Several cow-derived pure bone mineral blocks the size of sugar lumps where then put inside the structure, along with a human growth factor that builds bone and a large squirt of blood extracted from the man's bone marrow, which contains stem cells.

The surgeons then implanted the mesh cage and its contents into the muscle below the patient's right shoulder blade. He was given no drugs, other than routine antibiotics to prevent infection from the surgery.

The implant was left in for seven weeks, when scans showed new bone formation. It was removed about eight weeks ago, along with some surrounding muscle and blood vessels, put in the man's mouth and connected to the blood vessels in his neck.

Scans showed new bone continued to form after the transplant.

Four weeks after the operation, the man ate a German sausage sandwich, his first real meal in nine years. He eats steak now, but complains to his doctor that because he has no teeth he has to cut it into such small pieces that by the time he gets to the end of the steak, it's cold.


CT scan shows new jaw in place.

He has reported no pain or any other difficulties associated with the transplant, Warnke said, adding that he hopes to be able to remove the mesh and implant teeth in the new jaw about a year from now.

Paul Brown, head of the Center for Tissue Regeneration Science at University College in London, said it's not clear any major scientific ground has been broken, and tests may not be able to show whether the new bone came from stem cells, rather than from the growth factor alone.

The operation put established techniques together, resembling a well-known experiment in which University of Massachusetts scientists grew a human ear using a mold on the back of a mouse in 1995, he said.

"If you put loads of blocks of bone mineral into a hole and you induce cellular activity by putting in growth factors, it's a standard approach that people have used to induce the body's own response,'' said Brown, who was not connected with the study. "Clearly some of them are going to work and it sounds like for this patient, this has worked.''

Biopsies of the jaw bone could later provide some answers on the quality of the bone, experts said.

"Just making the gross tissue shape right isn't really the problem,'' Brown said. "It's what the shape of the tissue is at the microscopic and ultramicroscopic level. That's the architecture which is so tricky and which is what gives function.''
Old 08-29-04, 02:54 PM
  #20  
DVD Talk Hall of Fame
 
Join Date: Aug 2000
Location: Ottawa
Posts: 9,975
Likes: 0
Received 0 Likes on 0 Posts
That rules!
Old 08-29-04, 03:01 PM
  #21  
Mod Emeritus
 
Join Date: Feb 1999
Location: Gone to the islands - 'til we meet again.
Posts: 19,053
Likes: 0
Received 0 Likes on 0 Posts
Originally posted by BizRodian
That rules!

Yup... really remarkable. Adult stem cell research appears capable of doing great things!
Old 08-29-04, 03:41 PM
  #22  
DVD Talk Hall of Fame
 
Join Date: Aug 2000
Location: Ottawa
Posts: 9,975
Likes: 0
Received 0 Likes on 0 Posts
Well, they don't know yet if it was the stem cells or not.

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is On
Trackbacks are Off
Pingbacks are Off
Refbacks are Off


Thread Tools
Search this Thread

Archive - Advertising - Cookie Policy - Privacy Statement - Terms of Service - Do Not Sell My Personal Information

Copyright 2018 MH Sub I, LLC dba Internet Brands. All rights reserved. Use of this site indicates your consent to the Terms of Use.