Actors positioned in star-making performances, but they still haven't hit it big
 

Josh Lucas - Hulk, Stealth, and Poseidon. (Sorry man, three strikes and you're out)

i wouldn't consider STEALTH or POSEIDON as "star-making" vehicles. you should check out UNDERTOW if you want a good josh lucas performance.

Edward Burns failed to do this (15 Minutes, Life or Something Like It, etc.)
and the winner of this thread had to be Thomas Jane. I feel bad for the poor guy. Film after film he stars in bombs hard and/or he doesnt seem to get the respect he should. The Mist, Dreamcatcher, Punisher, Sweetest Thing, Deep Blue Sea, etc.

Yea, Tom Jane wins.

Sean William Scott
Paul Walker

Josh Hartnett

Jude Law

Vin Diesel

I'm gonna say Isla Fisher -- Really she's headlining her own movie?

Guy Pierce? Great movies, great performances, yet hasn't had his due yet.

Mark Ruffalo?

Brad Pitt. He can't open a movie. ;)

That Will Smith guy... Its never happening so maybe he should just go back to rappin'.

Chris O'Donnell was supposed to be the next Tom Cruise, but that didn't work out.

Edward Burns...I really thought he'd be a bigger star.

Ryan Reynolds