David and Paige Walling (Hugh Laurie, Catherine Keener) and Terry and Cathy Ostroff (Oliver Platt, Allison Janney) are best friends and neighbors living on Orange Drive in suburban New Jersey. Their comfortable existence goes awry when prodigal daughter Nina Ostroff (Leighton Meester), newly broken up with her fiancé Ethan (Sam Rosen), returns home for Thanksgiving after a five-year absence. Rather than developing an interest in the successful son of her neighbors, Toby Walling (Adam Brody), which would please both families, it's her parents' best friend David who captures Nina's attention.