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Old 04-27-13, 02:09 PM   #1
Dr Mabuse
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Scientists May Be On The Brink Of A Cure For HIV

Man if this pans out would that be huge or what? So many lives would be changed for the better in such profound ways.


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Scientists May Be On The Brink Of A Cure For HIV

Jake Wallis-Simons, The Daily Telegraph | Apr. 27, 2013, 2:58 PM | 0 |

HIV VirusResearchers believe that there will be a breakthrough in finding a cure for HIV “within months”.

Danish scientists are expecting results that will show that “finding a mass-distributable and affordable cure to HIV is possible”.

They are conducting clinical trials to test a “novel strategy” in which the HIV virus is stripped from human DNA and destroyed permanently by the immune system.

The move would represent a dramatic step forward in the attempt to find a cure for the virus, which causes Aids.

The scientists are currently conducting human trials on their treatment, in the hope of proving that it is effective. It has already been found to work in laboratory tests.

The technique involves releasing the HIV virus from “reservoirs” it forms in DNA cells, bringing it to the surface of the cells. Once it comes to the surface, the body’s natural immune system can kill the virus through being boosted by a “vaccine”.

In vitro studies — those that use human cells in a laboratory — of the new technique proved so successful that in January, the Danish Research Council awarded the team 12 million Danish kroner (£1.5 million) to pursue their findings in clinical trials with human subjects.

These are now under way, and according to Dr Søgaard, the early signs are “promising”.

Dr Ole Søgaard, a senior researcher at the Aarhus University Hospital in Denmark who is leading the study said: “I am almost certain that we will be successful in releasing the reservoirs of HIV.

“The challenge will be getting the patients’ immune system to recognise the virus and destroy it. This depends on the strength and sensitivity of individual immune systems.”

Fifteen patients are currently taking part in the trials, and if they are found to have successfully been cured of HIV, the “cure” will be tested on a wider scale.

Dr Søgaard stressed that a cure is not the same as a preventative vaccine, and that raising awareness of unsafe behaviour, including unprotected sex and sharing needles, remains of paramount importance in combating HIV.

With modern HIV treatment, a patient can live an almost normal life, even into old age, with limited side effects.

However, if medication is stopped, HIV reservoirs become active and start to produce more of the virus, meaning that symptoms can reappear within two weeks.

Finding a cure would free a patient from the need to take continuous HIV medication, and save health services billions of pounds.

The technique is being researched in Britain, but studies have not yet moved on to the clinical trial stage. Five universities — Oxford, Cambridge, Imperial College, London, University College, London and King’s College, London — have jointly formed the Collaborative HIV Eradication of Reservoirs UK Biomedical Research Centre group (CHERUB), which is dedicated to finding an HIV cure.

They have applied to the Medical Research Council for funding to conduct clinical trials, which will seek to combine techniques to release the reservoirs of HIV with immunotherapy to destroy the virus.

In addition, they are focusing on patients that have only recently been infected, as they believe this will improve chances of a cure. The group hopes to receive a funding decision in May.

“When the first patient is cured in this way it will be a spectacular moment,” says Dr John Frater, a clinical research fellow at the Nuffield School of Medicine, Oxford University, and a member of the CHERUB group.

“It will prove that we are heading in the right direction and demonstrate that a cure is possible. But I think it will be five years before we see a cure that can be offered on a large scale.”

The Danish team’s research is among the most advanced and fast moving in the world, as that they have streamlined the process of putting the latest basic science discoveries into clinical testing.

This means that researchers can progress more quickly to clinical trials, accelerating the process and reaching reliable results sooner than many others.

The technique uses drugs called HDAC Inhibitors, which are more commonly used in treating cancer, to drive out the HIV from a patient’s DNA. The Danish researchers are using a particularly powerful type of HDAC inhibitor called Panobinostat.

Five years ago, the general consensus was that HIV could not be cured. But then Timothy Ray Brown, an HIV sufferer — who has become known in the field as the Berlin Patient — developed leukaemia.

He had a bone marrow transplant from a donor with a rare genetic mutation that made his cells resistant to HIV. As a result, in 2007 Mr Brown became the first man to ever be fully cured of the disease.

Replicating this procedure on a mass scale is impossible. Nevertheless, the Brown case caused a sea change in research, with scientists focusing on finding a cure as well as suppressing the symptoms.

Two principal approaches are currently being pursued. The first, gene therapy, aims to make a patient’s immune system resistant to HIV. This is complex and expensive, and not easily transferrable to diverse gene pools around the world.

The second approach is the one being pursued by Dr Søgaard’s and his colleagues in Denmark, the CHERUB group in Britain, and by other laboratories in the United States and Europe.
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Old 04-27-13, 02:12 PM   #2
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Re: Scientists May Be On The Brink Of A Cure For HIV

If this pans out, even some DVDTalkers may get laid that night!
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Old 04-27-13, 02:14 PM   #3
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Re: Scientists May Be On The Brink Of A Cure For HIV

Woohoo! *throws away condoms*

Oh, right...pregnancy. *rummages through trash looking for condoms*
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Old 04-27-13, 02:19 PM   #4
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Re: Scientists May Be On The Brink Of A Cure For HIV

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Woohoo! *throws away condoms*

Oh, right...pregnancy. *rummages through trash looking for condoms*
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Old 04-27-13, 02:22 PM   #5
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Re: Scientists May Be On The Brink Of A Cure For HIV

We have a greenlight for fucking, i repeat greenlight for fucking.
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Old 04-27-13, 02:40 PM   #6
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Re: Scientists May Be On The Brink Of A Cure For HIV

Otter meetup at Steamworks!
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Old 04-27-13, 02:42 PM   #7
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Re: Scientists May Be On The Brink Of A Cure For HIV

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Otter meetup at Steamworks!
I already miss HIV.
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Old 04-27-13, 03:10 PM   #8
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Re: Scientists May Be On The Brink Of A Cure For HIV

Now if they can just find a cure for nerd, I will be having sex very soon!
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Old 04-27-13, 03:14 PM   #9
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Re: Scientists May Be On The Brink Of A Cure For HIV

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Otter meetup at Steamworks!
*Jules oils up.*
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Old 04-27-13, 03:15 PM   #10
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Re: Scientists May Be On The Brink Of A Cure For HIV

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I already miss HIV.


Awesome stuff though. I love science.
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Old 04-27-13, 03:48 PM   #11
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Re: Scientists May Be On The Brink Of A Cure For HIV

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*Jules oils up.*
Avoid steamworks ... they still haven't cured Herpes!
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Old 04-27-13, 03:57 PM   #12
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Re: Scientists May Be On The Brink Of A Cure For HIV

I'll bring my Donna Summer and Barbra Streisand records.
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Old 04-27-13, 04:06 PM   #13
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Re: Scientists May Be On The Brink Of A Cure For HIV

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Avoid steamworks ... they still haven't cured Herpes!
You can live a long time with herpes though. I think the reason there hasn't been an Otter skeet up is because of HIV. We're all totally fine with all the other STD's.
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Old 04-27-13, 04:20 PM   #14
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Re: Scientists May Be On The Brink Of A Cure For HIV

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Now if they can just find a cure for nerd, I will be having sex very soon!
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Old 04-27-13, 05:47 PM   #15
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Re: Scientists May Be On The Brink Of A Cure For HIV

This is awesome news.

I'm talking about the steamworks meet.
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Old 04-27-13, 06:08 PM   #16
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Re: Scientists May Be On The Brink Of A Cure For HIV

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Woohoo! *throws away condoms*

Oh, right...pregnancy. *rummages through trash looking for condoms*
Back where they came from, huh?
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Old 04-27-13, 06:10 PM   #17
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Re: Scientists May Be On The Brink Of A Cure For HIV

You ever get the feeling that you were born a generation too early? Right about the time we're all dying off, they're going to find cures for tons of diseases, they're going to break the genetic code to longer lifespans, they're going to come out with stem cell treatments for everything from male pattern baldness to missing limbs. Yep, all right about the time the last of us dies off. Bastards.
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Old 04-27-13, 06:16 PM   #18
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Re: Scientists May Be On The Brink Of A Cure For HIV

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You ever get the feeling that you were born a generation too early? Right about the time we're all dying off, they're going to find cures for tons of diseases, they're going to break the genetic code to longer lifespans, they're going to come out with stem cell treatments for everything from male pattern baldness to missing limbs. Yep, all right about the time the last of us dies off. Bastards.
Yeah, I've often thought of that too. C'mon science, hurry up, I'm not gonna be around forever!
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Old 04-27-13, 06:41 PM   #19
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Re: Scientists May Be On The Brink Of A Cure For HIV

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Originally Posted by Numanoid View Post
You ever get the feeling that you were born a generation too early? Right about the time we're all dying off, they're going to find cures for tons of diseases, they're going to break the genetic code to longer lifespans, they're going to come out with stem cell treatments for everything from male pattern baldness to missing limbs. Yep, all right about the time the last of us dies off. Bastards.
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Yeah, I've often thought of that too. C'mon science, hurry up, I'm not gonna be around forever!
I'm 32 right now and I feel like we're going to be able to stop aging about 25 years after I would be happy stopping it.
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Old 04-27-13, 06:53 PM   #20
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Re: Scientists May Be On The Brink Of A Cure For HIV

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You ever get the feeling that you were born a generation too early? Right about the time we're all dying off, they're going to find cures for tons of diseases, they're going to break the genetic code to longer lifespans, they're going to come out with stem cell treatments for everything from male pattern baldness to missing limbs. Yep, all right about the time the last of us dies off. Bastards.
I just want to transfer my consciousness to a robot body

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Old 04-27-13, 07:08 PM   #21
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Re: Scientists May Be On The Brink Of A Cure For HIV

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You ever get the feeling that you were born a generation too early?
I'd imagine 75-100 years from now cancer and HIV will be viewed as tuberculosis is by today's society. Diseases of a bygone era. Exciting to think about but aggravating to think we're gonna miss it by a few years. Of course, once those are cured there will be something new that's life threatening.
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Old 04-27-13, 07:16 PM   #22
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Re: Scientists May Be On The Brink Of A Cure For HIV

Why didn't they just inject people with Magic Johnson's blood? That shit cures everything.
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Old 04-27-13, 07:33 PM   #23
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Re: Scientists May Be On The Brink Of A Cure For HIV

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I'd imagine 75-100 years from now cancer and HIV will be viewed as tuberculosis is by today's society. Diseases of a bygone era. Exciting to think about but aggravating to think we're gonna miss it by a few years. Of course, once those are cured there will be something new that's life threatening.
No doubt. Years from now when there's some disease that makes balls and tits explode, people will say, 'Shit, I wish I just had HIV.'
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Old 04-27-13, 07:34 PM   #24
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Re: Scientists May Be On The Brink Of A Cure For HIV

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I just want to transfer my consciousness to a robot body
Ha, I've been telling everyone that warns me about the way I eat and drink that I'm counting on an android body since the '80s. I thought we'd be a lot closer by now. Come on, Science!
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Old 04-27-13, 08:29 PM   #25
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Re: Scientists May Be On The Brink Of A Cure For HIV

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You ever get the feeling that you were born a generation too early? Right about the time we're all dying off, they're going to find cures for tons of diseases, they're going to break the genetic code to longer lifespans, they're going to come out with stem cell treatments for everything from male pattern baldness to missing limbs. Yep, all right about the time the last of us dies off. Bastards.
That's why I don't recycle. Screw you future generations!
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